Title : Effect of ranitidine on ileal myenteric plexus preparation and on acetyl- and butyrylcholinesterase.

Pub. Date : 1984 Jun 15

PMID : 6329222






4 Functional Relationships(s)
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1 In order to identify the mechanism of these apparently cholinomimetic actions, the effects of ranitidine on AChE and BuChE were studied. Ranitidine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 It appears that ranitidine exerts an inhibition of the "mixed" type on both AChE and BuChE, but the dissociation constants for BuChE were markedly higher than those for AChE. Ranitidine acetylcholinesterase (Cartwright blood group) Homo sapiens
3 It appears that ranitidine exerts an inhibition of the "mixed" type on both AChE and BuChE, but the dissociation constants for BuChE were markedly higher than those for AChE. Ranitidine acetylcholinesterase (Cartwright blood group) Homo sapiens
4 Since AChE inhibition occurs in the same concentration range potentiating the twitch responses on the ileal myenteric preparation, it may explain the cholinomimetic effect of ranitidine. Ranitidine acetylcholinesterase (Cartwright blood group) Homo sapiens