Title : Clonidine antagonism of angiotensin-related drinking: a central site of action.

Pub. Date : 1984 Apr 30

PMID : 6326953






4 Functional Relationships(s)
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1 Administration of either isoproterenol (25 micrograms/kg, s.c.) or angiotensin II (200 micrograms/kg, s.c.) induces drinking in rats within 0.5-1 h. This drinking was inhibited by prior administration of the presynaptic alpha-adrenergic agonist clonidine (12 micrograms/kg, i.p.). Clonidine angiotensinogen Rattus norvegicus
2 Urine output was enhanced by clonidine in the angiotensin II-, but not the isoproterenol-treated group. Clonidine angiotensinogen Rattus norvegicus
3 This dose of clonidine also enhanced the urine output after angiotensin II. Clonidine angiotensinogen Rattus norvegicus
4 administration of angiotensin II, at 4 but not 20 ng/kg was inhibited by peripheral administration of clonidine (12 micrograms/kg, i.p.). Clonidine angiotensinogen Rattus norvegicus