Pub. Date : 1984 Mar
PMID : 6326866
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using antibodies against electrophoretically homogeneous cytochrome P-448 from rat liver microsomes induced by 3-methylcholanthrene, the changes in the immunologic identity and contents by cytochrome P-448 induced by 3-methylcholanthrene, 3.4-benzpyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), were studied. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | On the other hand, 3-methylcholanthrene, 3,4-benzpyrene and TCDD significantly and equally activates the cytochrome P-448-dependent benzpyrene hydroxylase, since the antibodies against cytochrome P-448 inhibit benzpyrene metabolism in the microsomes by 85-90%. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | On the other hand, 3-methylcholanthrene, 3,4-benzpyrene and TCDD significantly and equally activates the cytochrome P-448-dependent benzpyrene hydroxylase, since the antibodies against cytochrome P-448 inhibit benzpyrene metabolism in the microsomes by 85-90%. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 4 | The possible reasons for the TCDD-induced increase in the catalytic activity of cytochrome P-448 as compared to the immunologically identical cytochrome P-448 induced by 3-methylcholanthrene and 3,4-benzpyrene, are discussed. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 5 | The possible reasons for the TCDD-induced increase in the catalytic activity of cytochrome P-448 as compared to the immunologically identical cytochrome P-448 induced by 3-methylcholanthrene and 3,4-benzpyrene, are discussed. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |