Pub. Date : 1984 Apr 16
PMID : 6324792
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thrombin stimulation of human blood platelets caused an extensive (up to 45%) and rapid (5-10 s) decline in endogenous phosphatidylinositol 4,5-bisphosphate (PI-P2). | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |
| 2 | Thrombin stimulation of human blood platelets caused an extensive (up to 45%) and rapid (5-10 s) decline in endogenous phosphatidylinositol 4,5-bisphosphate (PI-P2). | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |
| 3 | Thrombin-induced decreases in PI-P2 content could account for release of sufficient membrane-bound Ca to raise cytoplasmic free [Ca2+] to 1-2 microM, supporting the hypothesis that PI-P2 represents the Ca-binding site involved in the stimulus-dependent increase in cytoplasmic Ca2+ evoked by receptor-ligand interactions. | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |
| 4 | Thrombin-induced decreases in PI-P2 content could account for release of sufficient membrane-bound Ca to raise cytoplasmic free [Ca2+] to 1-2 microM, supporting the hypothesis that PI-P2 represents the Ca-binding site involved in the stimulus-dependent increase in cytoplasmic Ca2+ evoked by receptor-ligand interactions. | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |