Title : Altered arachidonate metabolism by leukocytes and platelets in myeloproliferative disorders.

Pub. Date : 1983 Nov

PMID : 6318227






1 Functional Relationships(s)
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1 When the leukocytes were incubated with arachidonate and A23187, leukotriene B4 and hydroxyeicosatetraenoic acids (HETEs) were constantly detected using reversed-phase high-performance liquid chromatography in normal subjects, while selective deficiency of 5-lipoxygenase products (leukotriene B4 and 5-HETE) was found in 4 patients with CML. Arachidonic Acid arachidonate 5-lipoxygenase Homo sapiens