Title : Inhibition of dihydropteridine reductase by catechol estrogens.

Pub. Date : 1983

PMID : 6315964






1 Functional Relationships(s)
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1 Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups are methylated. 2-hydroxyestradiol quinoid dihydropteridine reductase Homo sapiens