Pub. Date : 1983 Aug 25
PMID : 6309775
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice. | Phenobarbital | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Southern blot analysis suggests that multiple sequences homologous to a phenobarbital-inducible cytochrome P-450 cDNA are present in the rat and mouse genomes. | Phenobarbital | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 3 | A cDNA (pP-450b-5) to a major phenobarbital-inducible cytochrome P-450 mRNA species in the rat detected 6 polymorphic DNA fragments when hybridized to DNA from C57BL/6J and DBA/2J mice restricted with endonucleases EcoRI, BamHI, and PvuII. | Phenobarbital | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 4 | The Coh locus has previously been shown to code for a phenobarbital-inducible enzyme, believed to be a cytochrome P-450, which catalyzes the conversion of coumarin to 7-hydroxycoumarin (umbelliferone). | Phenobarbital | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |