Pub. Date : 1983 Oct
PMID : 6309288
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As previously demonstrated with neutrophils, MPO-deficient monocytes had a greater initial rate, duration, and total superoxide production in response to phagocytosis of zymosan than did normal monocytes. | Zymosan | myeloperoxidase | Homo sapiens |
| 2 | Introduction of purified eosinophil peroxidase (EPO) into the phagosome by binding the enzyme to the surface of the zymosan particles changed the hypermetabolic characteristics of superoxide production in MPO-deficient cells to more closely resemble normal cells, but had no effect on superoxide generation by the normal monocytes. | Zymosan | myeloperoxidase | Homo sapiens |
| 3 | Iodination by MPO-deficient monocytes was significantly depressed as compared to normal monocytes following the ingestion of zymosan (1.9 versus 10.1 nmole I-/10(7) monocytes/30 min; p less than 0.01). | Zymosan | myeloperoxidase | Homo sapiens |
| 4 | In contrast, iodination was markedly augmented in MPO-deficient cells compared to normal cells after ingestion of zymosan coated with EPO (208 versus 70 nmole I-/10(7) monocytes/30 min; p less than 0.005), presumably reflecting the greater amounts of hydrogen peroxide formed by MPO-deficient cells. | Zymosan | myeloperoxidase | Homo sapiens |