Title : Prostaglandin synthetase and cytochrome P-450-dependent metabolism of (+/-)benzo(a)pyrene 7,8-dihydrodiol by enriched populations of rat Clara cells and alveolar type II cells.

Pub. Date : 1983 Jun

PMID : 6303564






1 Functional Relationships(s)
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1 Amounts of BP diol-epoxide I-derived tetrols formed from BP-7,8-diol by the prostaglandin synthetase-dependent and the cytochrome P-450-dependent pathways varied significantly between the two pulmonary cell fractions examined. Benzo(a)pyrene cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus