Pub. Date : 1983 Feb
PMID : 6298084
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined the relationship between the ability of I-3-C to alter the activity of hepatic aryl hydrocarbon hydroxylase (AHH), and its ability to inhibit the covalent binding of benzo[a]pyrene (BaP) metabolites to DNA and protein. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Using an in vitro system and a hepatic postmitochondrial fraction from mice that had been treated by gavage with I-3-C, we found that up to 90% of the covalent binding of BaP metabolites to macromolecules was eliminated, while AHH activity was unchanged. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |