Pub. Date : 1982
PMID : 6287499
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The hypothesis that pargyline, a monoamine oxidase inhibitor, may interact with pineal beta-adrenergic receptors to increase N-acetyltransferase (NAT) activity and, thereby, melatonin content was tested in intact and superior cervical ganglionectomized (SCGX) rats some of which were also treated with the tryptophan hydroxylase inhibitor para-chlorophenylalanine (PCPA). | Pargyline | N-acetyltransferase 1 | Rattus norvegicus |
| 2 | Pargyline injection increased both NAT activity and melatonin content, an effect nullified by conjunct propranolol injection. | Pargyline | N-acetyltransferase 1 | Rattus norvegicus |
| 3 | While pargyline injection also increased NAT activity in intact, PCPA-treated rats, the effects of this drug were most evident in SCGX, PCPA-treated rats. | Pargyline | N-acetyltransferase 1 | Rattus norvegicus |
| 4 | We suggest that pargyline may be capable of interacting with pineal beta-adrenergic receptors to increase NAT activity in the absence of pineal norepinephrine (NE) and serotonin. | Pargyline | N-acetyltransferase 1 | Rattus norvegicus |