Title : Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation.

Pub. Date : 1982 Sep

PMID : 6286728






3 Functional Relationships(s)
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1 The model hydrogen peroxide-myeloperoxidase-chloride system is capable of generating the powerful oxidant hypochlorous acid, which can be quantitated by trapping the generated species with the beta-amino acid, taurine. Chlorides myeloperoxidase Homo sapiens
2 Using this system, purified myeloperoxidase in the presence of chloride and taurine converted stoichiometric quantities of hydrogen peroxide to taurine chloramine. Chlorides myeloperoxidase Homo sapiens
3 Thus, it appears that stimulated human neutrophils can utilize the hydrogen peroxide-myeloperoxidase-chloride system to generate taurine chloramine. Chlorides myeloperoxidase Homo sapiens