Title : Modulation of peripheral adrenergic neurotransmission by methionine-enkephalin.

Pub. Date : 1982 May

PMID : 6281410






2 Functional Relationships(s)
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1 Perfusion of spleens with Met-enkephalin (10(-8)-10(-5) M) produced a dose-dependent decrease in the release of endogenous norepinephrine upon nerve stimulation. Norepinephrine proopiomelanocortin Homo sapiens
2 These findings support the hypothesis that the opiate receptor population in peripheral tissues are heterogenous and that Met-enkephalin depresses exocytotic release of norepinephrine by interacting with a specific presynaptic opiate receptor. Norepinephrine proopiomelanocortin Homo sapiens