Pub. Date : 1982 Apr
PMID : 6278020
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Chemotactic factor inactivation by stimulated human neutrophils mediated by myeloperoxidase-catalyzed methionine oxidation. | Methionine | myeloperoxidase | Homo sapiens |
2 | Paper chromatography demonstrated that exposure of a formyl-methionyl peptide chemotactic factor to either the cellfree myeloperoxidase system or stimulated neutrophils resulted in its conversion to a molecular species whose location in the chromatographs was identical to that of the peptide containing oxidized methionine. | Methionine | myeloperoxidase | Homo sapiens |
3 | Thus, stimulated human neutrophils inactivate peptide chemoattractants by secretion of myeloperoxidase and H2O2, which combine with halides to form oxidants that react with a critical methionine residue. | Methionine | myeloperoxidase | Homo sapiens |