Title : Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes.

Pub. Date : 1981 Nov 10

PMID : 6270135






2 Functional Relationships(s)
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1 In contrast, an inhibitory effect of flavone on benzo[a]pyrene metabolism was observed when cytochrome P-450LM2, cytochrome P-450LM3b, or cytochrome P-450LM6 was used in the reconstituted system. Benzo(a)pyrene cytochrome P450 2B4 Oryctolagus cuniculus
2 Smaller effects of 7,8-benzoflavone were observed on the metabolism of benzo[a]pyrene by the cytochrome P-450LM2-, cytochrome P-450LM3b-, and cytochrome P-450LM4-dependent monooxygenase systems. Benzo(a)pyrene cytochrome P450 2B4 Oryctolagus cuniculus