Title : A possible antihypertensive mechanism of propranolol: antagonism of angiotensin II enhancement of sympathetic nerve transmission through prostaglandins.

Pub. Date : 1981 Jan-Feb

PMID : 6259059






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1 A possible antihypertensive mechanism of propranolol: antagonism of angiotensin II enhancement of sympathetic nerve transmission through prostaglandins. Propranolol angiotensinogen Rattus norvegicus
2 The dl-propranolol had no effect on the basal vasoconstrictor responses to NS and NE, yet inhibited the AII-enhanced vasoconstrictor responses to NS by 47% (p less than 0.05) and 81% (p less than 0.001) at 100 and 300 ng/ml respectively. Propranolol angiotensinogen Rattus norvegicus
3 A similar blockade of AII enhancement of NS was observed with the d-isomer of propranolol. Propranolol angiotensinogen Rattus norvegicus
4 Indomethacin, a prostaglandin synthetase inhibitor (5 mg/kg, s.c.), abolished the inhibitory effect of dl-propranolol on AII enhancement of NS. Propranolol angiotensinogen Rattus norvegicus
5 We conclude that propranolol antagonizes AII enhancement of NS by increasing prostaglandin levels in vascular tissue. Propranolol angiotensinogen Rattus norvegicus