Pub. Date : 1981 Jan-Feb
PMID : 6259059
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A possible antihypertensive mechanism of propranolol: antagonism of angiotensin II enhancement of sympathetic nerve transmission through prostaglandins. | Propranolol | angiotensinogen | Rattus norvegicus |
| 2 | The dl-propranolol had no effect on the basal vasoconstrictor responses to NS and NE, yet inhibited the AII-enhanced vasoconstrictor responses to NS by 47% (p less than 0.05) and 81% (p less than 0.001) at 100 and 300 ng/ml respectively. | Propranolol | angiotensinogen | Rattus norvegicus |
| 3 | A similar blockade of AII enhancement of NS was observed with the d-isomer of propranolol. | Propranolol | angiotensinogen | Rattus norvegicus |
| 4 | Indomethacin, a prostaglandin synthetase inhibitor (5 mg/kg, s.c.), abolished the inhibitory effect of dl-propranolol on AII enhancement of NS. | Propranolol | angiotensinogen | Rattus norvegicus |
| 5 | We conclude that propranolol antagonizes AII enhancement of NS by increasing prostaglandin levels in vascular tissue. | Propranolol | angiotensinogen | Rattus norvegicus |