Title : Lysomotropic amines cause intracellular accumulation of receptors for epidermal growth factor.

Pub. Date : 1980 Jun

PMID : 6251452






1 Functional Relationships(s)
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1 Furthermore, 125I-labeled EGF incubated with cells in the presence of methylamine becomes increasingly insensitive to trypsin with time, suggesting that the EGF receptor internalization is not prevented by alkylamines, but that there is an intracellular accumulation of ligand--receptor complex due to the loss of normal modes of ligand-induced receptor processing. Iodine-125 epidermal growth factor receptor Homo sapiens