Pub. Date : 1984 Jun 1
PMID : 6234678
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tripeptide derivatives of lysyl or arginyl chloromethylketone inhibit the trypsin-like serine proteases trypsin, thrombin, plasmin, Factor Xa, urokinase, tissue-type plasminogen activator and protein Ca following the reaction scheme: (formula; see text) Extremely potent tripeptide inhibitors were obtained for thrombin and trypsin (k2/Ki greater than 10(6) M-1s-1), moderate inhibitors for plasmin and Factor Xa (10(6) M-1s-1 greater than k2/Ki greater than 10(4) M-1s-1) and only weak inhibitors for urokinase, tissue-type plasminogen activator and protein Ca (k2/Ki less than 10(4) M-1s-1). | tripeptide K-26 | plasminogen | Homo sapiens |
| 2 | Tripeptide derivatives of lysyl or arginyl chloromethylketone inhibit the trypsin-like serine proteases trypsin, thrombin, plasmin, Factor Xa, urokinase, tissue-type plasminogen activator and protein Ca following the reaction scheme: (formula; see text) Extremely potent tripeptide inhibitors were obtained for thrombin and trypsin (k2/Ki greater than 10(6) M-1s-1), moderate inhibitors for plasmin and Factor Xa (10(6) M-1s-1 greater than k2/Ki greater than 10(4) M-1s-1) and only weak inhibitors for urokinase, tissue-type plasminogen activator and protein Ca (k2/Ki less than 10(4) M-1s-1). | tripeptide K-26 | plasminogen | Homo sapiens |