Title : Possible resolution of a paradox concerning the use of p-chlorophenylalanine and 5-hydroxytryptophan: evidence for a mode of action involving adrenaline in manipulating the surge of luteinizing hormone in rats.

Pub. Date : 1983 Mar

PMID : 6222267






1 Functional Relationships(s)
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1 Phenylethanolamine N-methyltransferase, the enzyme responsible for converting noradrenaline to adrenaline, is shown to be inhibited in vivo by p-chlorophenylalanine and in vitro by its metabolite, p-chlorophenylethylamine. Norepinephrine phenylethanolamine-N-methyltransferase Rattus norvegicus