Pub. Date : 1983 Apr 14
PMID : 6219709
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The importance of the lysine binding sites of human plasmin for its ability to digest human fibrinogen has been assessed by analyzing the nature and rate of the products formed in the presence of epsilon-aminocaproic acid. | Aminocaproic Acid | plasminogen | Homo sapiens |
| 2 | The presence of epsilon-aminocaproic acid, at concentrations ranging from 0.5-5.0 mM, results in progressively stronger inhibition of the digestion of fibrinogen and in appearance of fibrinogen degradation products Y, D and E, for both Lys77-plasmin, and Val442-plasmin, showing the importance of lysine binding regions in this property. | Aminocaproic Acid | plasminogen | Homo sapiens |
| 3 | The presence of epsilon-aminocaproic acid, at concentrations ranging from 0.5-5.0 mM, results in progressively stronger inhibition of the digestion of fibrinogen and in appearance of fibrinogen degradation products Y, D and E, for both Lys77-plasmin, and Val442-plasmin, showing the importance of lysine binding regions in this property. | Aminocaproic Acid | plasminogen | Homo sapiens |
| 4 | However, since both plasmin forms were inhibited equally well at all levels of epsilon-aminocaproic acid, these studies show that lysine binding sites other than those present on region K 1-4 of Lys77-plasmin are of primary importance to fibrinogenolysis by plasmin. | Aminocaproic Acid | plasminogen | Homo sapiens |