Title : Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II).

Pub. Date : 1984 Dec

PMID : 6209003






2 Functional Relationships(s)
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Protein Name
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1 When diethyldithiocarbamate (4 to 15 mM) was incubated with alpha 2-macroglobulin and cisplatin, protein inactivation and cross-linking were totally prevented. Ditiocarb alpha-2-macroglobulin Homo sapiens
2 In experiments with alpha 2-macroglobulin-platinum(II) complex, purified by gel filtration chromatography, 1.0 mM diethyldithiocarbamate completely reactivated the protein and eliminated nearly all of the intersubunit cross-links. Ditiocarb alpha-2-macroglobulin Homo sapiens