Title : Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.

Pub. Date : 1984 Sep

PMID : 6208480






3 Functional Relationships(s)
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1 The receptor was phosphorylated on serine and threonine residues in normally growing and quiescent cells, and treatment with EGF or the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a two- to threefold increase in receptor-bound phosphate. Tetradecanoylphorbol Acetate epidermal growth factor Homo sapiens
2 Prior treatment with TPA inhibited the EGF-dependent appearance of phosphotyrosine in the receptor. Tetradecanoylphorbol Acetate epidermal growth factor Homo sapiens
3 Treatment of cells with TPA before addition of EGF inhibited all three of these EGF-dependent responses. Tetradecanoylphorbol Acetate epidermal growth factor Homo sapiens