Pub. Date : 1984
PMID : 6206352
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In conscious rats with established deoxycorticosterone acetate (DOCA)/salt hypertension, d(CH2)5 Tyr (Me) AVP decreased systolic BP after acute administration. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 2 | In conscious rats with established deoxycorticosterone acetate (DOCA)/salt hypertension, d(CH2)5 Tyr (Me) AVP decreased systolic BP after acute administration. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 3 | When another, AVP-antagonist, d(CH2)5-D-Tyr (Et) VAVP, which blocks vascular and renal tubular AVP-receptors, was administered chronically, the development of DOCA/salt hypertension was prevented at the expense of severe and persistent hypernatremia. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 4 | When another, AVP-antagonist, d(CH2)5-D-Tyr (Et) VAVP, which blocks vascular and renal tubular AVP-receptors, was administered chronically, the development of DOCA/salt hypertension was prevented at the expense of severe and persistent hypernatremia. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 5 | These results demonstrate that under certain conditions the vascular effects of AVP may contribute to the maintenance of BP, AVP appears to participate in the pathogenesis of DOCA/salt hypertension through both its vasoconstrictor and its antidiuretic effects. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |