Pub. Date : 1978 Feb
PMID : 620441
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of suppression of renin secretion by clonidine in the dog. | Clonidine | renin | Canis lupus familiaris |
| 2 | The mechanism by which clonidine suppresses renin secretion was investigated in pentobarbital-anesthetized dogs in which renal perfusion pressure was controlled by means of an aortic clamp. | Clonidine | renin | Canis lupus familiaris |
| 3 | Clonidine (30 microgram/kg, iv) lowered mean arterial pressure (MAP) from 124 +/- 8 to 104 +/- 4 mm Hg (P less than 0.01) and reduced plasma renin activity (PRA) to 32 +/- 4 percent of the control value (P less than 0.01) after 60 minutes. | Clonidine | renin | Canis lupus familiaris |
| 4 | Taken together, these data support the hypothesis that the inhibition of renin secretion by clonidine results from a centrally mediated decrease in sympathetic neural activity. | Clonidine | renin | Canis lupus familiaris |