Title : Lanthanides are transported by ionophore A23187 and mimic calcium in the histamine secretion process.

Pub. Date : 1983 Oct

PMID : 6197128






2 Functional Relationships(s)
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1 Calmodulin inhibitors, phenothiazines, R24571 and mepacrine, inhibited the histamine release induced by either calcium or lanthanides. Lanthanoid Series Elements calmodulin 1 Rattus norvegicus
2 These data show that ionophore A23187 can transport lanthanides across the plasma membrane of mast cells, allowing the trivalent cations to substitute for calcium in the activation of calmodulin or calmoduline-like proteins. Lanthanoid Series Elements calmodulin 1 Rattus norvegicus