Title : Facilitation of cAMP increments during ADCC mediated by monocytes pretreated with cAMP-elevating agents.

Pub. Date : 1983

PMID : 6192093






2 Functional Relationships(s)
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1 This increase in cAMP was facilitated when monocytes were preincubated with the phosphodiesterase inhibitors, isobutylmethylxanthine (IBMX) and theophylline, and the adenylate cyclase agonists, isoproterenol and prostaglandin E1 (PGE1). Theophylline cathelicidin antimicrobial peptide Homo sapiens
2 Theophylline in doses of 0.5 mM did not elevate basal levels of monocyte cAMP but facilitated the ADCC-induced cAMP increment concomitant with inhibition of monocyte ADCC and degranulation. Theophylline cathelicidin antimicrobial peptide Homo sapiens