Title : Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor.

Pub. Date : 1982 May

PMID : 6178113






3 Functional Relationships(s)
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1 Recently, it was found that the DNA alkylating agent ethyl methanesulfonate can induce the appearance of rPRL-deficient GH3 cell variants at a high frequency (ca. Ethyl Methanesulfonate prolactin Rattus norvegicus
2 Furthermore, the DNA methylation inhibitor 5-azacytidine reverted an ethyl methanesulfonate-induced rPRL-deficient variant into rPRL-expressing cells at high frequency (ca. Ethyl Methanesulfonate prolactin Rattus norvegicus
3 Furthermore, the DNA methylation inhibitor 5-azacytidine reverted an ethyl methanesulfonate-induced rPRL-deficient variant into rPRL-expressing cells at high frequency (ca. Ethyl Methanesulfonate prolactin Rattus norvegicus