Title : Captopril interferes with neurogenic vasoconstriction in the pithed rat by angiotensin-dependent mechanisms.

Pub. Date : 1982 Jan-Feb

PMID : 6176786






2 Functional Relationships(s)
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1 In a pithed rat preparation the vasoconstrictor responses to both nerve stimulation (1-30 Hz) and exogenous noradrenaline (10-500 ng) were reduced by the ACE inhibitors captopril (0.1 and 1 mg/kg) and SQ20881 (10 mg/kg), and by the angiotensin II antagonist [Sar1 Ala8]angiotensin II (4 micrograms/kg/min). Norepinephrine angiotensinogen Rattus norvegicus
2 In a pithed rat preparation the vasoconstrictor responses to both nerve stimulation (1-30 Hz) and exogenous noradrenaline (10-500 ng) were reduced by the ACE inhibitors captopril (0.1 and 1 mg/kg) and SQ20881 (10 mg/kg), and by the angiotensin II antagonist [Sar1 Ala8]angiotensin II (4 micrograms/kg/min). Norepinephrine angiotensinogen Rattus norvegicus