Title : Stimulation of human gamma interferon production by diterpene esters.

Pub. Date : 1981 Oct

PMID : 6170583






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Mezerein, a structurally related diterpene ester, was at least as active as TPA in stimulating IFN production in either Ficoll-Hypaque-purified or unprocessed cells. mezerein interferon alpha 1 Homo sapiens
2 IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta. mezerein interferon alpha 1 Homo sapiens
3 IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta. mezerein interferon alpha 1 Homo sapiens