Title : Eosinophil peroxidase-induced mast cell secretion.

Pub. Date : 1980 Aug 1

PMID : 6156983






5 Functional Relationships(s)
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1 Eosinophil peroxidase (EPO) at relatively low levels (4-30 mU), when supplemented with H2O2 and a halide, induced mast cell degranulation. Hydrogen Peroxide eosinophil peroxidase Homo sapiens
2 Eosinophil peroxidase (EPO) at relatively low levels (4-30 mU), when supplemented with H2O2 and a halide, induced mast cell degranulation. Hydrogen Peroxide eosinophil peroxidase Homo sapiens
3 When the EPO level was increased to 100 mU, combination with H2O2- and iodide-induced cytotoxic histamine release as indicated by concomitant LDH release and ultrastructural evidence of cell disruption. Hydrogen Peroxide eosinophil peroxidase Homo sapiens
4 The mast cell granule (MCG)/EPO complex when supplemented with H2O2 and iodide was more effective than free EPO in the stimulation of mast cell secretion. Hydrogen Peroxide eosinophil peroxidase Homo sapiens
5 The stimulation of mast cell mediator release by the EPO-H2O2-halide system and the formation of MCG/EPO complexes with augmented cytotoxic activity may influence the adjacent inflammatory response. Hydrogen Peroxide eosinophil peroxidase Homo sapiens