Title : 2'-Deoxy-2'-azidoadenosine triphosphate and 2'-deoxy-2'-fluoroadenosine triphosphate as substrates and inhibitors for Escherichia coli DNA-dependent RNA polymerase.

Pub. Date : 1980 Mar

PMID : 6156150






2 Functional Relationships(s)
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1 In the presence of UTP, 2"-deoxy-2"-azidoadenosine 5"-triphosphate (AZTP) was incorporated into an acid-insoluble fraction at one-tenth of the rate of ATP incorporation; it thus acts as a competitive inhibitor for poly(AU) synthesis. Gold Dopamine transporter Drosophila melanogaster
2 On the other hand, another ATP analog, 2"-deoxy-2"-fluoroadenosine 5"-triphosphate (AfTP), was co-polymerized with UTP into acid-insoluble materials at a rate less than 1% of that of ATP incorporation; in addition, it exerted a strong but mixed-type inhibition on poly(AU) synthesis. Gold Dopamine transporter Drosophila melanogaster