Pub. Date : 1984 Dec
PMID : 6149821
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of chronic phenobarbital administration on the gamma-glutamyl transpeptidase activity of hyperplastic liver lesions induced in rats by the Solt/Farber initiation: selection process of hepatocarcinogenesis. | Phenobarbital | gamma-glutamyltransferase 1 | Rattus norvegicus |
| 2 | A chronic 8 to 11 week administration of the hepatic tumor promoter phenobarbital (0.05% in drinking water) to rats previously subjected to the initiation:selection process of Solt and Farber was found to further increase the gamma-glutamyl transpeptidase activity of individual hyperplastic liver nodules of 4.0-10.0 mm in diameter over comparably sized nodules from control livers. | Phenobarbital | gamma-glutamyltransferase 1 | Rattus norvegicus |
| 3 | In addition, random tissue samples of non-nodular liver taken from the 11 week phenobarbital-treated rats exhibited a gamma-glutamyl transpeptidase mean specific activity which was approximately 3 times higher than that of control non-nodular liver samples. | Phenobarbital | gamma-glutamyltransferase 1 | Rattus norvegicus |
| 4 | In contrast, there was a 1.5-fold increase in the mean % gamma-glutamyl transpeptidase-positive area (cm2), as determined histochemically, in cryostat sections made from non-nodular samples of the 11 week phenobarbital-treated rats when compared with that of control liver sections. | Phenobarbital | gamma-glutamyltransferase 1 | Rattus norvegicus |
| 5 | Interruption of the chronic phenobarbital administration at 8 weeks followed by 3 weeks of control treatment resulted in a reversal of the gamma-glutamyl transpeptidase activity response shown by the hyperplastic liver nodules and non-nodular liver tissue samples. | Phenobarbital | gamma-glutamyltransferase 1 | Rattus norvegicus |
| 6 | Thus, phenobarbital can quantitatively modulate gamma-glutamyl transpeptidase activity in carcinogen-induced hyperplastic liver lesions in the rat during the early stages of hepatocarcinogenesis. | Phenobarbital | gamma-glutamyltransferase 1 | Rattus norvegicus |