Title : Lack of initiating or promoting activity of six benzodiazepine tranquilizers in rat liver limited bioassays monitored by histopathology and assay of liver and plasma enzymes.

Pub. Date : 1984 Apr

PMID : 6144610






1 Functional Relationships(s)
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1 Administration of phenobarbital after N-2-fluorenylacetamide resulted in an elevation of liver and plasma gamma-glutamyltranspeptidase, but none of the benzodiazepines produced this effect and thus no biochemical evidence of a promoting effect on the liver was observed. Phenobarbital gamma-glutamyltransferase 1 Rattus norvegicus