Title : pH-dependent rearrangement of the biosynthetic ester glucuronide of valproic acid to beta-glucuronidase-resistant forms.

Pub. Date : 1984 Mar-Apr

PMID : 6144492






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A major metabolite of the antiepileptic drug valproic acid (VPA) in animals and man is the glucuronic acid conjugate, which is cleaved by incubation with beta-glucuronidase (specific for 1-O-substituted-beta-D-glucopyranosiduronic acids) or hydrolysis in strong acid or alkali. Glucuronic Acid glucuronidase beta Homo sapiens