Title : Regulation of progestin biosynthetic enzymes in cultured rat granulosa cells: effects of prolactin, beta 2-adrenergic agonist, human chorionic gonadotropin and gonadotropin releasing hormone.

Pub. Date : 1983 Oct

PMID : 6138106






3 Functional Relationships(s)
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1 In contrast, treatment with Prl or terbutaline, but not hCG, inhibited 20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) activity by decreasing the apparent maximal velocity of the enzyme with no change in its Km value. Terbutaline aldo-keto reductase family 1, member C3 Rattus norvegicus
2 In contrast, treatment with Prl or terbutaline, but not hCG, inhibited 20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) activity by decreasing the apparent maximal velocity of the enzyme with no change in its Km value. Terbutaline aldo-keto reductase family 1, member C3 Rattus norvegicus
3 The inhibitory effect of GnRH on Prl- or terbutaline-stimulated progesterone production appears to result from a preferential increase in 20 alpha-HSD activity, while the GnRH inhibition of hCG-stimulated progesterone production appears to result from a preferential inhibition of pregnenolone production. Terbutaline aldo-keto reductase family 1, member C3 Rattus norvegicus