Title : The effect of chronic antidepressant administration on beta-adrenoceptor function of the rat pineal.

Pub. Date : 1983 Jan

PMID : 6130811






1 Functional Relationships(s)
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1 The beta(2)-adrenoceptor agonist, terbutaline (5.0 mg kg(-1)), produced a moderate increase in pineal melatonin content.2 Repeated daily administration of desmethylimipramine (10 mg kg(-1) for 10 days) and maprotiline (10 mg kg(-1) for 10 days), antidepressants predominantly inhibiting noradrenaline (NA) uptake, reduced the isoprenaline-induced increase in pineal melatonin content. Terbutaline adrenoceptor beta 2 Rattus norvegicus