Title : Cytochrome P-450-dependent covalent binding of 1,1,2,2-tetrachloroethane in vitro.

Pub. Date : 1982 Sep-Oct

PMID : 6128194






1 Functional Relationships(s)
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1 The results are consistent with a scheme whereby 1,1,2,2-tetrachloroethane is metabolized by cytochrome P-450 to dichloroacetyl chloride, which can bind covalently to various nucleophiles or hydrolyze to dichloroacetic acid. Dichloroacetic Acid cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus