Title : The effect of morphine, naloxone, D- and L-aspartic acid on the brain and lung ACE in mice.

Pub. Date : 1983 Nov

PMID : 6101060






4 Functional Relationships(s)
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1 The brain and lung angiotensin converting enzyme (ACE) activities of the mice injected with 10 mg/kg morphine and/or naloxone, 200 mg/kg D- and/or L-aspartic acid were spectrophotometrically determined. Aspartic Acid angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus
2 Morphine, naloxone, D- and L-aspartic acid alone inhibited both brain and lung ACE activities whereas the combinations of morphine with naloxone, D-aspartic acid with L-aspartic acid and morphine with naloxone + L-aspartic acid showed no inhibitory effect on the brain ACE. Aspartic Acid angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus
3 While naloxone or L-aspartic acid partly antagonized the suppression of morphine on the lung ACE their combination completely prevented morphine from inhibiting the lung ACE. Aspartic Acid angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus
4 While naloxone or L-aspartic acid partly antagonized the suppression of morphine on the lung ACE their combination completely prevented morphine from inhibiting the lung ACE. Aspartic Acid angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus