Title : Effect of central administration of MK-422 (the diacid form of enalapril) on the development of hypertension in the spontaneously hypertensive rat.

Pub. Date : 1984 Dec

PMID : 6100756






1 Functional Relationships(s)
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1 In conclusion, both captopril and MK-422 prevent the development of hypertension in SHR, presumably by blocking angiotensin-converting enzyme, suggesting that the brain renin-angiotensin system contributes to the pathogenesis of hypertension in that model. Enalaprilat renin Rattus norvegicus