Title : Receptor-binding properties of gonadotropin-releasing hormone derivatives. Prolonged receptor occupancy and cell-surface localization of a potent antagonist analog.

Pub. Date : 1984 Oct 25

PMID : 6092341






2 Functional Relationships(s)
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1 In rat pituitary particles and isolated pituitary cells, the 125I-labeled GnRH antagonist showed saturable high-affinity binding (Ka v 8.4 +/- 1.4 X 10(9) M-1) to the same receptor sites which bound the GnRH agonist. Iodine-125 gonadotropin releasing hormone 1 Rattus norvegicus
2 In rat pituitary particles and isolated pituitary cells, the 125I-labeled GnRH antagonist showed saturable high-affinity binding (Ka v 8.4 +/- 1.4 X 10(9) M-1) to the same receptor sites which bound the GnRH agonist. Iodine-125 gonadotropin releasing hormone 1 Rattus norvegicus