Title : Humoral factors involved in the regulation of sodium-fluid balance in normal man. II. Effect of indomethacin on sodium concentration, renal prostaglandins, vasopressin and renin-angiotensin-aldosterone system.

Pub. Date : 1984

PMID : 6091412






2 Functional Relationships(s)
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1 Indomethacin inhibition of PG-synthesis was performed, and after high-Na provocation, an increase of vasopressin and cyclic AMP excretion by 15% and 376% more than that without indomethacin was found. Prostaglandins arginine vasopressin Homo sapiens
2 The results confirmed the assumption that renal prostaglandins are modulators of renin release from the kidney and that they alternate vasopressin effect on urine concentration, most probably through adenylate cyclase-cAMP system. Prostaglandins arginine vasopressin Homo sapiens