Title : An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations.

Pub. Date : 1984 Aug 15

PMID : 6089756






5 Functional Relationships(s)
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1 An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations. Cyclic AMP insulin Homo sapiens
2 The ability of insulin (10 nM) to decrease intracellular cyclic AMP concentrations raised by glucagon (10 nM) was unaffected by pre-treatment with either NH4Cl (10 mM) or fructose (10 mM). Cyclic AMP insulin Homo sapiens
3 When N6-(phenylisopropyl)adenosine was used to prevent glucagon from blocking insulin"s activation of the plasma-membrane cyclic AMP phosphodiesterase activity, insulin"s ability to decrease intracellular cyclic AMP concentrations in glucagon-treated hepatocytes was increased markedly. Cyclic AMP insulin Homo sapiens
4 When N6-(phenylisopropyl)adenosine was used to prevent glucagon from blocking insulin"s activation of the plasma-membrane cyclic AMP phosphodiesterase activity, insulin"s ability to decrease intracellular cyclic AMP concentrations in glucagon-treated hepatocytes was increased markedly. Cyclic AMP insulin Homo sapiens
5 Insulin"s activation of the plasma-membrane cyclic AMP phosphodiesterase activity can exert a potent effect in decreasing intracellular cyclic AMP concentrations elevated by glucagon. Cyclic AMP insulin Homo sapiens