Title : Antagonistic effect of theophylline on the adenosine-induced decreased in renin release.

Pub. Date : 1984 Aug

PMID : 6087679






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1 Antagonistic effect of theophylline on the adenosine-induced decreased in renin release. Theophylline renin Canis lupus familiaris
2 The action of theophylline on the adenosine-induced decrease in renin release was studied in anesthetized dogs. Theophylline renin Canis lupus familiaris
3 Theophylline (5 mumol/min intrarenally) had no significant effect on GFR or RBF yet produced a significant increase in the release of renin and the fractional excretion of sodium. Theophylline renin Canis lupus familiaris
4 Theophylline at 5 X 10(-6) mol/min, which stimulates renin release and effectively antagonizes the renal effects of adenosine, had no detectable effect on cAMP measured in renal cortex. Theophylline renin Canis lupus familiaris
5 These findings demonstrate that theophylline, at concentrations having no effect on cortical cAMP, antagonizes the effect of adenosine on renin release. Theophylline renin Canis lupus familiaris
6 The results are also consistent with the view that theophylline stimulates renin release by a mechanism other than its action on cAMP. Theophylline renin Canis lupus familiaris