Title : Metabolism and exretion of 3-hydroxyphenyltrimethylammonium and neostigmine.

Pub. Date : 1969 Feb

PMID : 5774048






2 Functional Relationships(s)
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1 Carbon-14 labelled 3-hydroxyphenyltrimethylammonium (3-OH PTMA), an active metabolite of neostigmine, has been given to rats by intramuscular injection and its excretion, distribution and metabolism have been studied.2. Neostigmine prothymosin alpha Rattus norvegicus
2 It is concluded that the duration of action of neostigmine is determined by its rapid renal excretion and by its metabolism to the glucuronide conjugate of 3-OH PTMA. Neostigmine prothymosin alpha Rattus norvegicus