Pub. Date : 1971 Jul
PMID : 5283959
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous studies have shown that the vitamin K-induced synthesis of prothrombin in a vitamin K-deficient rat is only slightly inhibited by cycloheximide treatment. | Cycloheximide | coagulation factor II | Rattus norvegicus |
| 2 | When cycloheximide (5 mg/kg) was given to vitamin K-deficient rats 30 min before vitamin K, about 70% of the amount of prothrombin seen in rats not treated with cycloheximide was produced (two-stage assay), and the prothrombin band could be seen on the electrophoretic gels. | Cycloheximide | coagulation factor II | Rattus norvegicus |
| 3 | When cycloheximide (5 mg/kg) was given to vitamin K-deficient rats 30 min before vitamin K, about 70% of the amount of prothrombin seen in rats not treated with cycloheximide was produced (two-stage assay), and the prothrombin band could be seen on the electrophoretic gels. | Cycloheximide | coagulation factor II | Rattus norvegicus |
| 4 | However, if radioactive amino acids are administered to the rats after cycloheximide treatment, the newly formed prothrombin contains no radioactivity. | Cycloheximide | coagulation factor II | Rattus norvegicus |
| 5 | The isolated prothrombin does contain radioactivity if the vitamin K-deficient rats are treated with vitamin K but no cycloheximide. | Cycloheximide | coagulation factor II | Rattus norvegicus |