Title : Synthesis of angiotensin II antagonists containing sarcosine in position 7.

Pub. Date : 1979 Sep

PMID : 490564






1 Functional Relationships(s)
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1 Analogues of the type [1-sarcosine,7-sarcosine, 8-X]angiotensin II, where X = isoleucine, leucine, alanine, methionine, O-methylthreonine, or DL-alloisoleucine, were synthesized by the solid-phase method and purified by partition chromatography, cation-exchange chromatography, and high-pressure liquid chromatography. Leucine angiotensinogen Rattus norvegicus