Pub. Date : 1979 Sep
PMID : 467810
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acetylsalicyclic acid restores acute insulin response reduced by furosemide in man. | Furosemide | insulin | Homo sapiens |
| 2 | Infusion of lysine acetylsalicylate (LAS), an inhibitor of endogenous PGE synthesis, completely reversed the inhibitory effect of furosemide on insulin secretion and also augmented acute insulin response to glucose (response before furosemide + LAS: 41 +/- 6 muU/ml; during furosemide + LAS: 50 +/- 7 muU/ml, N = 10, P less than 0.02). | Furosemide | insulin | Homo sapiens |
| 3 | These findings demonstrate that (1) furosemide inhibits glucose-induced acute insulin responses and (2) LAS completely reverses the inhibitory effect of furosemide and also accelerates glucose disposal. | Furosemide | insulin | Homo sapiens |
| 4 | It is suggested that furosemide acts via the release of endogenous PGEs, which are known to inhibit insulin responses in man. | Furosemide | insulin | Homo sapiens |