Title : Control of circadian change of serotonin N-acetyltransferase activity in the pineal organ by the beta--adrenergic receptor.

Pub. Date : 1972 Sep

PMID : 4506772






1 Functional Relationships(s)
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1 Treatment with reserpine, a compound that depletes norepinephrine from nerves, 1-propranolol, a beta-adrenergic blocking agent, or cycloheximide, an inhibitor of protein synthesis, abolishes the nocturnal increase in serotonin N-acetyltransferase activity, indicating that the enzyme activity is modulated by neural release of norepinephrine from sympathetic nerves via beta-adrenergic receptors, and that the increase in enzyme activity is due to synthesis of new enzyme molecules. Cycloheximide aralkylamine N-acetyltransferase Rattus norvegicus