Title : Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.

Pub. Date : 1985 Dec 15

PMID : 3935115






1 Functional Relationships(s)
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1 This study compared the NADH- and NADPH-supported p-nitrophenetole (NP) O-deethylase, ethylmorphine (EM) O-deethylase and EM N-demethylase activities of rat hepatic microsomes with respect to dioxygen requirement, inhibition by carbon monoxide, inhibition by classical inhibitors of cytochrome P-450 systems, and the involvement of NADH-cytochrome b5, cytochrome b5 reductase and NADPH-cytochrome P-450 reductase. NADP cytochrome p450 oxidoreductase Rattus norvegicus