Title : Degradation of insulin by human fibroblasts: effects of inhibitors of pinocytosis and lysosomal activity.

Pub. Date : 1985

PMID : 3902530






1 Functional Relationships(s)
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1 The role of the pinosome-lysosome pathway in the degradation of 125I-labelled bovine insulin by cultured human fibroblasts was examined by comparing the effects of various known inhibitors of pinocytosis and lysosomal degradation on the uptake and degradation of 125I-labelled polyvinylpyrrolidone, formaldehyde-denatured bovine serum albumin and bovine insulin by these cells. Iodine-125 insulin Bos taurus